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Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.

Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hype...

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Autores principales: Colleti Junior, Jose, Carla Armelin Benites, Eliana, Spadaccia dos Santos Fernandes, Gustavo, Antonio Freddi, Norberto, Koga, Walter, Brunow de Carvalho, Werther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505782/
https://www.ncbi.nlm.nih.gov/pubmed/26213611
http://dx.doi.org/10.12688/f1000research.6393.1
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author Colleti Junior, Jose
Carla Armelin Benites, Eliana
Spadaccia dos Santos Fernandes, Gustavo
Antonio Freddi, Norberto
Koga, Walter
Brunow de Carvalho, Werther
author_facet Colleti Junior, Jose
Carla Armelin Benites, Eliana
Spadaccia dos Santos Fernandes, Gustavo
Antonio Freddi, Norberto
Koga, Walter
Brunow de Carvalho, Werther
author_sort Colleti Junior, Jose
collection PubMed
description Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits.
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spelling pubmed-45057822015-07-24 Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. Colleti Junior, Jose Carla Armelin Benites, Eliana Spadaccia dos Santos Fernandes, Gustavo Antonio Freddi, Norberto Koga, Walter Brunow de Carvalho, Werther F1000Res Case Report Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits. F1000Research 2015-05-11 /pmc/articles/PMC4505782/ /pubmed/26213611 http://dx.doi.org/10.12688/f1000research.6393.1 Text en Copyright: © 2015 Colleti Junior J et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Case Report
Colleti Junior, Jose
Carla Armelin Benites, Eliana
Spadaccia dos Santos Fernandes, Gustavo
Antonio Freddi, Norberto
Koga, Walter
Brunow de Carvalho, Werther
Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title_full Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title_fullStr Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title_full_unstemmed Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title_short Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
title_sort case report: pulmonary alveolar calcification as a result of severe hypercalcemia due to acute lymphoblatic leukemia.
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505782/
https://www.ncbi.nlm.nih.gov/pubmed/26213611
http://dx.doi.org/10.12688/f1000research.6393.1
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