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Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia.
Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hype...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505782/ https://www.ncbi.nlm.nih.gov/pubmed/26213611 http://dx.doi.org/10.12688/f1000research.6393.1 |
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author | Colleti Junior, Jose Carla Armelin Benites, Eliana Spadaccia dos Santos Fernandes, Gustavo Antonio Freddi, Norberto Koga, Walter Brunow de Carvalho, Werther |
author_facet | Colleti Junior, Jose Carla Armelin Benites, Eliana Spadaccia dos Santos Fernandes, Gustavo Antonio Freddi, Norberto Koga, Walter Brunow de Carvalho, Werther |
author_sort | Colleti Junior, Jose |
collection | PubMed |
description | Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits. |
format | Online Article Text |
id | pubmed-4505782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-45057822015-07-24 Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. Colleti Junior, Jose Carla Armelin Benites, Eliana Spadaccia dos Santos Fernandes, Gustavo Antonio Freddi, Norberto Koga, Walter Brunow de Carvalho, Werther F1000Res Case Report Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits. F1000Research 2015-05-11 /pmc/articles/PMC4505782/ /pubmed/26213611 http://dx.doi.org/10.12688/f1000research.6393.1 Text en Copyright: © 2015 Colleti Junior J et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). |
spellingShingle | Case Report Colleti Junior, Jose Carla Armelin Benites, Eliana Spadaccia dos Santos Fernandes, Gustavo Antonio Freddi, Norberto Koga, Walter Brunow de Carvalho, Werther Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title | Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title_full | Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title_fullStr | Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title_full_unstemmed | Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title_short | Case Report: Pulmonary Alveolar Calcification as a Result of Severe Hypercalcemia due to Acute Lymphoblatic Leukemia. |
title_sort | case report: pulmonary alveolar calcification as a result of severe hypercalcemia due to acute lymphoblatic leukemia. |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505782/ https://www.ncbi.nlm.nih.gov/pubmed/26213611 http://dx.doi.org/10.12688/f1000research.6393.1 |
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