Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development

The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of...

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Detalles Bibliográficos
Autores principales: Swat, MJ, Moodie, S, Wimalaratne, SM, Kristensen, NR, Lavielle, M, Mari, A, Magni, P, Smith, MK, Bizzotto, R, Pasotti, L, Mezzalana, E, Comets, E, Sarr, C, Terranova, N, Blaudez, E, Chan, P, Chard, J, Chatel, K, Chenel, M, Edwards, D, Franklin, C, Giorgino, T, Glont, M, Girard, P, Grenon, P, Harling, K, Hooker, AC, Kaye, R, Keizer, R, Kloft, C, Kok, JN, Kokash, N, Laibe, C, Laveille, C, Lestini, G, Mentré, F, Munafo, A, Nordgren, R, Nyberg, HB, Parra-Guillen, ZP, Plan, E, Ribba, B, Smith, G, Trocóniz, IF, Yvon, F, Milligan, PA, Harnisch, L, Karlsson, M, Hermjakob, H, Le Novère, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505825/
https://www.ncbi.nlm.nih.gov/pubmed/26225259
http://dx.doi.org/10.1002/psp4.57
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author Swat, MJ
Moodie, S
Wimalaratne, SM
Kristensen, NR
Lavielle, M
Mari, A
Magni, P
Smith, MK
Bizzotto, R
Pasotti, L
Mezzalana, E
Comets, E
Sarr, C
Terranova, N
Blaudez, E
Chan, P
Chard, J
Chatel, K
Chenel, M
Edwards, D
Franklin, C
Giorgino, T
Glont, M
Girard, P
Grenon, P
Harling, K
Hooker, AC
Kaye, R
Keizer, R
Kloft, C
Kok, JN
Kokash, N
Laibe, C
Laveille, C
Lestini, G
Mentré, F
Munafo, A
Nordgren, R
Nyberg, HB
Parra-Guillen, ZP
Plan, E
Ribba, B
Smith, G
Trocóniz, IF
Yvon, F
Milligan, PA
Harnisch, L
Karlsson, M
Hermjakob, H
Le Novère, N
author_facet Swat, MJ
Moodie, S
Wimalaratne, SM
Kristensen, NR
Lavielle, M
Mari, A
Magni, P
Smith, MK
Bizzotto, R
Pasotti, L
Mezzalana, E
Comets, E
Sarr, C
Terranova, N
Blaudez, E
Chan, P
Chard, J
Chatel, K
Chenel, M
Edwards, D
Franklin, C
Giorgino, T
Glont, M
Girard, P
Grenon, P
Harling, K
Hooker, AC
Kaye, R
Keizer, R
Kloft, C
Kok, JN
Kokash, N
Laibe, C
Laveille, C
Lestini, G
Mentré, F
Munafo, A
Nordgren, R
Nyberg, HB
Parra-Guillen, ZP
Plan, E
Ribba, B
Smith, G
Trocóniz, IF
Yvon, F
Milligan, PA
Harnisch, L
Karlsson, M
Hermjakob, H
Le Novère, N
author_sort Swat, MJ
collection PubMed
description The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.
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spelling pubmed-45058252015-07-22 Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development Swat, MJ Moodie, S Wimalaratne, SM Kristensen, NR Lavielle, M Mari, A Magni, P Smith, MK Bizzotto, R Pasotti, L Mezzalana, E Comets, E Sarr, C Terranova, N Blaudez, E Chan, P Chard, J Chatel, K Chenel, M Edwards, D Franklin, C Giorgino, T Glont, M Girard, P Grenon, P Harling, K Hooker, AC Kaye, R Keizer, R Kloft, C Kok, JN Kokash, N Laibe, C Laveille, C Lestini, G Mentré, F Munafo, A Nordgren, R Nyberg, HB Parra-Guillen, ZP Plan, E Ribba, B Smith, G Trocóniz, IF Yvon, F Milligan, PA Harnisch, L Karlsson, M Hermjakob, H Le Novère, N CPT Pharmacometrics Syst Pharmacol Perspective The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps. John Wiley & Sons, Ltd 2015-06 2015-06-15 /pmc/articles/PMC4505825/ /pubmed/26225259 http://dx.doi.org/10.1002/psp4.57 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective
Swat, MJ
Moodie, S
Wimalaratne, SM
Kristensen, NR
Lavielle, M
Mari, A
Magni, P
Smith, MK
Bizzotto, R
Pasotti, L
Mezzalana, E
Comets, E
Sarr, C
Terranova, N
Blaudez, E
Chan, P
Chard, J
Chatel, K
Chenel, M
Edwards, D
Franklin, C
Giorgino, T
Glont, M
Girard, P
Grenon, P
Harling, K
Hooker, AC
Kaye, R
Keizer, R
Kloft, C
Kok, JN
Kokash, N
Laibe, C
Laveille, C
Lestini, G
Mentré, F
Munafo, A
Nordgren, R
Nyberg, HB
Parra-Guillen, ZP
Plan, E
Ribba, B
Smith, G
Trocóniz, IF
Yvon, F
Milligan, PA
Harnisch, L
Karlsson, M
Hermjakob, H
Le Novère, N
Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title_full Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title_fullStr Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title_full_unstemmed Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title_short Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
title_sort pharmacometrics markup language (pharmml): opening new perspectives for model exchange in drug development
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505825/
https://www.ncbi.nlm.nih.gov/pubmed/26225259
http://dx.doi.org/10.1002/psp4.57
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