A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mat...

Descripción completa

Detalles Bibliográficos
Autores principales: Dua, P, Hawkins, E, van der Graaf, PH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505827/
https://www.ncbi.nlm.nih.gov/pubmed/26225261
http://dx.doi.org/10.1002/psp4.41
_version_ 1782381592138743808
author Dua, P
Hawkins, E
van der Graaf, PH
author_facet Dua, P
Hawkins, E
van der Graaf, PH
author_sort Dua, P
collection PubMed
description Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.
format Online
Article
Text
id pubmed-4505827
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley & Sons, Ltd
record_format MEDLINE/PubMed
spelling pubmed-45058272015-07-22 A Tutorial on Target-Mediated Drug Disposition (TMDD) Models Dua, P Hawkins, E van der Graaf, PH CPT Pharmacometrics Syst Pharmacol Tutorial Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials. John Wiley & Sons, Ltd 2015-06 2015-06-15 /pmc/articles/PMC4505827/ /pubmed/26225261 http://dx.doi.org/10.1002/psp4.41 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tutorial
Dua, P
Hawkins, E
van der Graaf, PH
A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_full A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_fullStr A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_full_unstemmed A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_short A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_sort tutorial on target-mediated drug disposition (tmdd) models
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505827/
https://www.ncbi.nlm.nih.gov/pubmed/26225261
http://dx.doi.org/10.1002/psp4.41
work_keys_str_mv AT duap atutorialontargetmediateddrugdispositiontmddmodels
AT hawkinse atutorialontargetmediateddrugdispositiontmddmodels
AT vandergraafph atutorialontargetmediateddrugdispositiontmddmodels
AT duap tutorialontargetmediateddrugdispositiontmddmodels
AT hawkinse tutorialontargetmediateddrugdispositiontmddmodels
AT vandergraafph tutorialontargetmediateddrugdispositiontmddmodels

Ejemplares similares