Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

Herpes simplex virus 1 (HSV-1) ICP0 is a multi-functional phosphoprotein expressed with immediate early kinetics. An ICP0 deletion mutant, HSV-1 dl1403, has been widely used to study the roles of ICP0 in the HSV-1 replication cycle including gene expression, latency, entry and assembly. We show that...

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Detalles Bibliográficos
Autores principales: Cunha, Cristina W., Taylor, Kathryne E., Pritchard, Suzanne M., Delboy, Mark G., Komala Sari, Tri, Aguilar, Hector C., Mossman, Karen L., Nicola, Anthony V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505948/
https://www.ncbi.nlm.nih.gov/pubmed/26186447
http://dx.doi.org/10.1371/journal.pone.0131129

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