An Extended Polyanion Activation Surface in Insulin Degrading Enzyme

Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriuretic peptide. IDE is activated toward some substrate...

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Detalles Bibliográficos
Autores principales: Song, Eun Suk, Ozbil, Mehmet, Zhang, Tingting, Sheetz, Michael, Lee, David, Tran, Danny, Li, Sheng, Prabhakar, Rajeev, Hersh, Louis B., Rodgers, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506039/
https://www.ncbi.nlm.nih.gov/pubmed/26186535
http://dx.doi.org/10.1371/journal.pone.0133114

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