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Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4(+) T Lymphocytes

Vpr is a conserved primate lentiviral protein that promotes infection of T lymphocytes in vivo by an unknown mechanism. Here we demonstrate that Vpr and its cellular co-factor, DCAF1, are necessary for efficient cell-to-cell spread of HIV-1 from macrophages to CD4(+) T lymphocytes when there is inad...

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Detalles Bibliográficos
Autores principales:	Collins, David R., Lubow, Jay, Lukic, Zana, Mashiba, Michael, Collins, Kathleen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506080/ https://www.ncbi.nlm.nih.gov/pubmed/26186441 http://dx.doi.org/10.1371/journal.ppat.1005054

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