Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target such mechanisms. A major challenge of the approach is the identification of the...

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Detalles Bibliográficos
Autores principales: Khare, Shilpi, Roach, Steven L., Barnes, S. Whitney, Hoepfner, Dominic, Walker, John R., Chatterjee, Arnab K., Neitz, R. Jeffrey, Arkin, Michelle R., McNamara, Case W., Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H., Glynne, Richard J., Supek, Frantisek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506092/
https://www.ncbi.nlm.nih.gov/pubmed/26186534
http://dx.doi.org/10.1371/journal.ppat.1005058

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