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Importins and exportins in cellular differentiation

The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed th...

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Autores principales: Okada, Norihisa, Ishigami, Yoko, Suzuki, Takuji, Kaneko, Akihiro, Yasui, Kensuke, Fukutomi, Ryuuta, Isemura, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506156/
https://www.ncbi.nlm.nih.gov/pubmed/18657223
http://dx.doi.org/10.1111/j.1582-4934.2008.00437.x
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author Okada, Norihisa
Ishigami, Yoko
Suzuki, Takuji
Kaneko, Akihiro
Yasui, Kensuke
Fukutomi, Ryuuta
Isemura, Mamoru
author_facet Okada, Norihisa
Ishigami, Yoko
Suzuki, Takuji
Kaneko, Akihiro
Yasui, Kensuke
Fukutomi, Ryuuta
Isemura, Mamoru
author_sort Okada, Norihisa
collection PubMed
description The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-α subtype triggers neural differentiation of embryonic stem cells underscores the importance of nucleocytoplasmic transport factors in cellular events. This review focuses on current research into the roles of importins and exportins in cell differentiation.
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spelling pubmed-45061562015-07-22 Importins and exportins in cellular differentiation Okada, Norihisa Ishigami, Yoko Suzuki, Takuji Kaneko, Akihiro Yasui, Kensuke Fukutomi, Ryuuta Isemura, Mamoru J Cell Mol Med Reviews The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-α subtype triggers neural differentiation of embryonic stem cells underscores the importance of nucleocytoplasmic transport factors in cellular events. This review focuses on current research into the roles of importins and exportins in cell differentiation. John Wiley & Sons, Ltd 2008-10 2008-07-24 /pmc/articles/PMC4506156/ /pubmed/18657223 http://dx.doi.org/10.1111/j.1582-4934.2008.00437.x Text en © 2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Okada, Norihisa
Ishigami, Yoko
Suzuki, Takuji
Kaneko, Akihiro
Yasui, Kensuke
Fukutomi, Ryuuta
Isemura, Mamoru
Importins and exportins in cellular differentiation
title Importins and exportins in cellular differentiation
title_full Importins and exportins in cellular differentiation
title_fullStr Importins and exportins in cellular differentiation
title_full_unstemmed Importins and exportins in cellular differentiation
title_short Importins and exportins in cellular differentiation
title_sort importins and exportins in cellular differentiation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506156/
https://www.ncbi.nlm.nih.gov/pubmed/18657223
http://dx.doi.org/10.1111/j.1582-4934.2008.00437.x
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