Disruption of the Smad7 gene enhances CCI(4)-dependent liver damage and fibrogenesis in mice

Transforming growth factor-β (TGF-β) signalling is induced in liver as a consequence of damage and contributes to wound healing with transient activation, whereas it mediates fibrogenesis with long-term up-regulation in chronic disease. Smad-dependent TGF-β effects are blunted by antagonistic Smad7,...

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Detalles Bibliográficos
Autores principales: Hamzavi, Jafar, Ehnert, Sabrina, Godoy, Patricio, Ciuclan, Loredana, Weng, Honglei, Mertens, Peter R, Heuchel, Rainer, Dooley, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506177/
https://www.ncbi.nlm.nih.gov/pubmed/18266971
http://dx.doi.org/10.1111/j.1582-4934.2008.00262.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506177/
https://www.ncbi.nlm.nih.gov/pubmed/18266971
http://dx.doi.org/10.1111/j.1582-4934.2008.00262.x

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