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Disruption of the Smad7 gene enhances CCI(4)-dependent liver damage and fibrogenesis in mice
Transforming growth factor-β (TGF-β) signalling is induced in liver as a consequence of damage and contributes to wound healing with transient activation, whereas it mediates fibrogenesis with long-term up-regulation in chronic disease. Smad-dependent TGF-β effects are blunted by antagonistic Smad7,...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506177/ https://www.ncbi.nlm.nih.gov/pubmed/18266971 http://dx.doi.org/10.1111/j.1582-4934.2008.00262.x |