Improving survival by exploiting tumor dependence on stabilized mutant p53 for treatment

Missense mutations in p53 generate aberrant proteins with abrogated tumor suppressor functions that can also acquire oncogenic gain-of-functions (GOF) that promote malignant progression, invasion, metastasis and chemoresistance(1–5). Mutant p53 (mutp53) proteins undergo massive constitutive stabiliz...

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Detalles Bibliográficos
Autores principales: Alexandrova, EM, Yallowitz, AR, Li, D, Xu, S, Schulz, R, Proia, DA, Lozano, G, Dobbelstein, M, Moll, UM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506213/
https://www.ncbi.nlm.nih.gov/pubmed/26009011
http://dx.doi.org/10.1038/nature14430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506213/
https://www.ncbi.nlm.nih.gov/pubmed/26009011
http://dx.doi.org/10.1038/nature14430

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