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Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

BACKGROUND: Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral heterogeneity impacts therapeutic outcome remain poorly understood. RNA sequencing (RNA-seq) of single tumor cells can provide comprehensive inform...

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Detalles Bibliográficos
Autores principales:	Kim, Kyu-Tae, Lee, Hye Won, Lee, Hae-Ock, Kim, Sang Cheol, Seo, Yun Jee, Chung, Woosung, Eum, Hye Hyeon, Nam, Do-Hyun, Kim, Junhyong, Joo, Kyeung Min, Park, Woong-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506401/ https://www.ncbi.nlm.nih.gov/pubmed/26084335 http://dx.doi.org/10.1186/s13059-015-0692-3

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