Atg1 family kinases in autophagy initiation

Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation....

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Detalles Bibliográficos
Autores principales: Noda, Nobuo N., Fujioka, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506457/
https://www.ncbi.nlm.nih.gov/pubmed/25948417
http://dx.doi.org/10.1007/s00018-015-1917-z
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author Noda, Nobuo N.
Fujioka, Yuko
author_facet Noda, Nobuo N.
Fujioka, Yuko
author_sort Noda, Nobuo N.
collection PubMed
description Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy.
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spelling pubmed-45064572015-07-20 Atg1 family kinases in autophagy initiation Noda, Nobuo N. Fujioka, Yuko Cell Mol Life Sci Review Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy. Springer Basel 2015-05-07 2015 /pmc/articles/PMC4506457/ /pubmed/25948417 http://dx.doi.org/10.1007/s00018-015-1917-z Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Noda, Nobuo N.
Fujioka, Yuko
Atg1 family kinases in autophagy initiation
title Atg1 family kinases in autophagy initiation
title_full Atg1 family kinases in autophagy initiation
title_fullStr Atg1 family kinases in autophagy initiation
title_full_unstemmed Atg1 family kinases in autophagy initiation
title_short Atg1 family kinases in autophagy initiation
title_sort atg1 family kinases in autophagy initiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506457/
https://www.ncbi.nlm.nih.gov/pubmed/25948417
http://dx.doi.org/10.1007/s00018-015-1917-z
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AT fujiokayuko atg1familykinasesinautophagyinitiation

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