Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Transverse and longitudinal relaxation times (T(1ρ) and T(1)) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand compris...

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Detalles Bibliográficos
Autores principales: Buratto, Roberto, Bornet, Aurélien, Milani, Jonas, Mammoli, Daniele, Vuichoud, Basile, Salvi, Nicola, Singh, Maninder, Laguerre, Aurélien, Passemard, Solène, Gerber-Lemaire, Sandrine, Jannin, Sami, Bodenhausen, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506523/
https://www.ncbi.nlm.nih.gov/pubmed/25196781
http://dx.doi.org/10.1002/cmdc.201402214

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