Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. Here, we report the first crystal structure of the human enzyme that reveals a pseudosymmetrical arrangement of two ca...

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Detalles Bibliográficos
Autores principales: Saalau-Bethell, Susanne M, Berdini, Valerio, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E, Lock, Victoria, Murray, Christopher W, O'Brien, M Alistair, Rich, Sharna J, Sambrook, Tracey, Vinkovic, Mladen, Yon, Jeff R, Jhoti, Harren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
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Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506562/
https://www.ncbi.nlm.nih.gov/pubmed/24616449
http://dx.doi.org/10.1002/cmdc.201300480

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