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Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex**
In investigating the binding interactions between the human telomeric RNA (TERRA) G-quadruplex (GQ) and its ligands, it was found that the small molecule carboxypyridostatin (cPDS) and the GQ-selective antibody BG4 simultaneously bind the TERRA GQ. We previously showed that the overall binding affin...
Autores principales: | Yangyuoru, Philip M, Di Antonio, Marco, Ghimire, Chiran, Biffi, Giulia, Balasubramanian, Shankar, Mao, Hanbin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506565/ https://www.ncbi.nlm.nih.gov/pubmed/25421962 http://dx.doi.org/10.1002/anie.201408113 |
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