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Spontaneous CO Release from Ru(II)(CO)(2)–Protein Complexes in Aqueous Solution, Cells, and Mice**

We demonstrate that Ru(II)(CO)(2)–protein complexes, formed by the reaction of the hydrolytic decomposition products of [fac-RuCl(κ(2)-H(2)NCH(2)CO(2))(CO)(3)] (CORM-3) with histidine residues exposed on the surface of proteins, spontaneously release CO in aqueous solution, cells, and mice. CO relea...

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Detalles Bibliográficos
Autores principales:	Chaves-Ferreira, Miguel, Albuquerque, Inês S, Matak-Vinkovic, Dijana, Coelho, Ana C, Carvalho, Sandra M, Saraiva, Lígia M, Romão, Carlos C, Bernardes, Gonçalo J L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506567/ https://www.ncbi.nlm.nih.gov/pubmed/25477186 http://dx.doi.org/10.1002/anie.201409344

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