A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities

BACKGROUND: The lymph node metastasis is a key early step of the tumor metastatic process. VEGFD-mediated tumor lymphangiogenesis plays a key role, since down-regulation of p-VEGFR-3 could block the lymph node metastasis. YL529 has been reported to possess potent anti-angiogenesis and antitumor acti...

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Detalles Bibliográficos
Autores principales: Xu, Youzhi, Lu, Wenjie, Yang, Peng, Peng, Wen, Wang, Chunting, Li, Manli, Li, Yan, Li, Guobo, Meng, Nana, Lin, Hongjun, Kan, Lixin, Wang, Siying, Yang, Shengyong, Yu, Luoting, Zhao, YingLan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506598/
https://www.ncbi.nlm.nih.gov/pubmed/26187637
http://dx.doi.org/10.1186/s12885-015-1451-2

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