Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to I...

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Autores principales: Baxa, Jan, Hromádka, Milan, Šedivý, Jakub, Štěpánková, Lucie, Moláček, Jiří, Schmidt, Bernhard, Flohr, Thomas, Ferda, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506745/
https://www.ncbi.nlm.nih.gov/pubmed/26236712
http://dx.doi.org/10.1155/2015/105629
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author Baxa, Jan
Hromádka, Milan
Šedivý, Jakub
Štěpánková, Lucie
Moláček, Jiří
Schmidt, Bernhard
Flohr, Thomas
Ferda, Jiří
author_facet Baxa, Jan
Hromádka, Milan
Šedivý, Jakub
Štěpánková, Lucie
Moláček, Jiří
Schmidt, Bernhard
Flohr, Thomas
Ferda, Jiří
author_sort Baxa, Jan
collection PubMed
description The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.
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spelling pubmed-45067452015-08-02 Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients Baxa, Jan Hromádka, Milan Šedivý, Jakub Štěpánková, Lucie Moláček, Jiří Schmidt, Bernhard Flohr, Thomas Ferda, Jiří Biomed Res Int Research Article The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40–70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA. Hindawi Publishing Corporation 2015 2015-07-05 /pmc/articles/PMC4506745/ /pubmed/26236712 http://dx.doi.org/10.1155/2015/105629 Text en Copyright © 2015 Jan Baxa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baxa, Jan
Hromádka, Milan
Šedivý, Jakub
Štěpánková, Lucie
Moláček, Jiří
Schmidt, Bernhard
Flohr, Thomas
Ferda, Jiří
Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_full Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_fullStr Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_full_unstemmed Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_short Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients
title_sort regadenoson-stress dynamic myocardial perfusion improves diagnostic performance of ct angiography in assessment of intermediate coronary artery stenosis in asymptomatic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506745/
https://www.ncbi.nlm.nih.gov/pubmed/26236712
http://dx.doi.org/10.1155/2015/105629
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