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Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma

BACKGROUND: Increasing evidence indicates that rapamycin could be used as a potential glucocorticoid (GC) sensitizer in lymphoblastic malignancies via genetic prevention of 4E-BP1 phosphorylation. Interestingly, we found that combined rapamycin with dexamethasone can effectively reverse GC resistanc...

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Detalles Bibliográficos
Autores principales:	Gu, Ling, Xie, Liping, Zuo, Chuan, Ma, Zhigui, Zhang, Yanle, Zhu, Yiping, Gao, Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506760/ https://www.ncbi.nlm.nih.gov/pubmed/26189041 http://dx.doi.org/10.1186/s12885-015-1535-z

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