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The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats

Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature. Objective. This study investigates the...

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Autores principales: Kunak, Celalettin Semih, Kukula, Osman, Mutlu, Emre, Genç, Fatma, Güleç Peker, Gülçer, Kuyrukluyıldız, Ufuk, Binici, Orhan, Altuner, Durdu, Alp, Hamit Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506808/
https://www.ncbi.nlm.nih.gov/pubmed/26236425
http://dx.doi.org/10.1155/2015/598162
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author Kunak, Celalettin Semih
Kukula, Osman
Mutlu, Emre
Genç, Fatma
Güleç Peker, Gülçer
Kuyrukluyıldız, Ufuk
Binici, Orhan
Altuner, Durdu
Alp, Hamit Hakan
author_facet Kunak, Celalettin Semih
Kukula, Osman
Mutlu, Emre
Genç, Fatma
Güleç Peker, Gülçer
Kuyrukluyıldız, Ufuk
Binici, Orhan
Altuner, Durdu
Alp, Hamit Hakan
author_sort Kunak, Celalettin Semih
collection PubMed
description Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature. Objective. This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver. Material and Methods. Experimental animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG). ETO-50 and ETO-100 groups were administered etoricoxib, while LIRC and HG groups were orally given distilled water by gavage. Hepatic artery was clamped for one hour to provide ischemia, and then reperfusion was provided for 6 hours. Oxidant, antioxidant, and COX-2 gene expressions were studied in the liver tissues. ALT and AST were measured. Results. Etoricoxib in 50 and 100 mg/kg doses changed the levels of oxidant/antioxidant parameters such as MDA, MPO, tGSH, GSHRd, GST, SOD, NO, and 8-OH/Gua in favour of antioxidants. Furthermore, etoricoxib prevented increase of COX-2 gene expression and ALT and AST levels. This important protective effect of etoricoxib on the rat liver I/R can be tested in the clinical setting.
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spelling pubmed-45068082015-08-02 The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats Kunak, Celalettin Semih Kukula, Osman Mutlu, Emre Genç, Fatma Güleç Peker, Gülçer Kuyrukluyıldız, Ufuk Binici, Orhan Altuner, Durdu Alp, Hamit Hakan Oxid Med Cell Longev Research Article Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature. Objective. This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver. Material and Methods. Experimental animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG). ETO-50 and ETO-100 groups were administered etoricoxib, while LIRC and HG groups were orally given distilled water by gavage. Hepatic artery was clamped for one hour to provide ischemia, and then reperfusion was provided for 6 hours. Oxidant, antioxidant, and COX-2 gene expressions were studied in the liver tissues. ALT and AST were measured. Results. Etoricoxib in 50 and 100 mg/kg doses changed the levels of oxidant/antioxidant parameters such as MDA, MPO, tGSH, GSHRd, GST, SOD, NO, and 8-OH/Gua in favour of antioxidants. Furthermore, etoricoxib prevented increase of COX-2 gene expression and ALT and AST levels. This important protective effect of etoricoxib on the rat liver I/R can be tested in the clinical setting. Hindawi Publishing Corporation 2015 2015-07-05 /pmc/articles/PMC4506808/ /pubmed/26236425 http://dx.doi.org/10.1155/2015/598162 Text en Copyright © 2015 Celalettin Semih Kunak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kunak, Celalettin Semih
Kukula, Osman
Mutlu, Emre
Genç, Fatma
Güleç Peker, Gülçer
Kuyrukluyıldız, Ufuk
Binici, Orhan
Altuner, Durdu
Alp, Hamit Hakan
The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title_full The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title_fullStr The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title_full_unstemmed The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title_short The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats
title_sort effect of etoricoxib on hepatic ischemia-reperfusion injury in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506808/
https://www.ncbi.nlm.nih.gov/pubmed/26236425
http://dx.doi.org/10.1155/2015/598162
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