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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506835/ https://www.ncbi.nlm.nih.gov/pubmed/26236580 http://dx.doi.org/10.1155/2015/897327 |
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author | Conti, V. Corbi, G. Manzo, V. Pelaia, G. Filippelli, A. Vatrella, A. |
author_facet | Conti, V. Corbi, G. Manzo, V. Pelaia, G. Filippelli, A. Vatrella, A. |
author_sort | Conti, V. |
collection | PubMed |
description | Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed. |
format | Online Article Text |
id | pubmed-4506835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45068352015-08-02 Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease Conti, V. Corbi, G. Manzo, V. Pelaia, G. Filippelli, A. Vatrella, A. Anal Cell Pathol (Amst) Review Article Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed. Hindawi Publishing Corporation 2015 2015-07-05 /pmc/articles/PMC4506835/ /pubmed/26236580 http://dx.doi.org/10.1155/2015/897327 Text en Copyright © 2015 V. Conti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Conti, V. Corbi, G. Manzo, V. Pelaia, G. Filippelli, A. Vatrella, A. Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title | Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title_full | Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title_fullStr | Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title_short | Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease |
title_sort | sirtuin 1 and aging theory for chronic obstructive pulmonary disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506835/ https://www.ncbi.nlm.nih.gov/pubmed/26236580 http://dx.doi.org/10.1155/2015/897327 |
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