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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molec...

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Detalles Bibliográficos
Autores principales: Conti, V., Corbi, G., Manzo, V., Pelaia, G., Filippelli, A., Vatrella, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506835/
https://www.ncbi.nlm.nih.gov/pubmed/26236580
http://dx.doi.org/10.1155/2015/897327
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author Conti, V.
Corbi, G.
Manzo, V.
Pelaia, G.
Filippelli, A.
Vatrella, A.
author_facet Conti, V.
Corbi, G.
Manzo, V.
Pelaia, G.
Filippelli, A.
Vatrella, A.
author_sort Conti, V.
collection PubMed
description Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed.
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spelling pubmed-45068352015-08-02 Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease Conti, V. Corbi, G. Manzo, V. Pelaia, G. Filippelli, A. Vatrella, A. Anal Cell Pathol (Amst) Review Article Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed. Hindawi Publishing Corporation 2015 2015-07-05 /pmc/articles/PMC4506835/ /pubmed/26236580 http://dx.doi.org/10.1155/2015/897327 Text en Copyright © 2015 V. Conti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Conti, V.
Corbi, G.
Manzo, V.
Pelaia, G.
Filippelli, A.
Vatrella, A.
Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title_full Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title_fullStr Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title_full_unstemmed Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title_short Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease
title_sort sirtuin 1 and aging theory for chronic obstructive pulmonary disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506835/
https://www.ncbi.nlm.nih.gov/pubmed/26236580
http://dx.doi.org/10.1155/2015/897327
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