Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target gene expression of YAP and TAZ. All three drugs ind...

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Detalles Bibliográficos
Autores principales: Oku, Yusuke, Nishiya, Naoyuki, Shito, Toshiya, Yamamoto, Reiichiro, Yamamoto, Yasufumi, Oyama, Chihiro, Uehara, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506957/
https://www.ncbi.nlm.nih.gov/pubmed/26199863
http://dx.doi.org/10.1016/j.fob.2015.06.007

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