Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Dominant mutations in five tRNA synthetases cause Charcot–Marie–Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease. However, previous studies showed that loss of aminoacylation activity is not required to cause CMT. Here we present a Drosophila model for CM...

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Detalles Bibliográficos
Autores principales: Niehues, Sven, Bussmann, Julia, Steffes, Georg, Erdmann, Ines, Köhrer, Caroline, Sun, Litao, Wagner, Marina, Schäfer, Kerstin, Wang, Guangxia, Koerdt, Sophia N., Stum, Morgane, RajBhandary, Uttam L., Thomas, Ulrich, Aberle, Hermann, Burgess, Robert W., Yang, Xiang-Lei, Dieterich, Daniela, Storkebaum, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506996/
https://www.ncbi.nlm.nih.gov/pubmed/26138142
http://dx.doi.org/10.1038/ncomms8520

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