A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenes...

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Detalles Bibliográficos
Autores principales: Abraham, Sabu, Scarcia, Margherita, Bagshaw, Richard D., McMahon, Kathryn, Grant, Gary, Harvey, Tracey, Yeo, Maggie, Esteves, Filomena O.G., Thygesen, Helene H., Jones, Pamela F., Speirs, Valerie, Hanby, Andrew M., Selby, Peter J., Lorger, Mihaela, Dear, T. Neil, Pawson, Tony, Marshall, Christopher J., Mavria, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507007/
https://www.ncbi.nlm.nih.gov/pubmed/26129894
http://dx.doi.org/10.1038/ncomms8286

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