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Wound healing: a new perspective on glucosylated tetrahydrocurcumin
Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507491/ https://www.ncbi.nlm.nih.gov/pubmed/26203224 http://dx.doi.org/10.2147/DDDT.S85041 |
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author | Bhaskar Rao, Adari Prasad, Ernala Deepthi, Seelam Siva Haritha, Vennapusa Ramakrishna, Sistla Madhusudan, Kuncha Surekha, Mullapudi Venkata Venkata Rao, Yerramilli Sri Rama |
author_facet | Bhaskar Rao, Adari Prasad, Ernala Deepthi, Seelam Siva Haritha, Vennapusa Ramakrishna, Sistla Madhusudan, Kuncha Surekha, Mullapudi Venkata Venkata Rao, Yerramilli Sri Rama |
author_sort | Bhaskar Rao, Adari |
collection | PubMed |
description | Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit a wide spectrum of biological activities similar to those of native curcuminoids. The poor bioavailability of these curcuminoids limits their clinical applications. The present study highlights the percutaneous absorption and wound healing activity of glucosyl-conjugated THC (glucosyl-THC) in male Wistar rats. A high plasma concentration of glucosyl-THC (4.35 μg/mL) was found in rats 3 hours after application. A significant enhanced wound healing activity and reduced epithelialization time were observed in rats that received glucosyl-THC. This may have been due to the improved bioavailability of the glucosyl compound. The nonstaining and lack of skin-sensitive side effects render the bioconjugated glucosyl-THC a promising therapeutic compound in the management of excision wounds and in cosmetic applications, in the near future. |
format | Online Article Text |
id | pubmed-4507491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45074912015-07-22 Wound healing: a new perspective on glucosylated tetrahydrocurcumin Bhaskar Rao, Adari Prasad, Ernala Deepthi, Seelam Siva Haritha, Vennapusa Ramakrishna, Sistla Madhusudan, Kuncha Surekha, Mullapudi Venkata Venkata Rao, Yerramilli Sri Rama Drug Des Devel Ther Original Research Wound healing represents a dynamic set of coordinated physiological processes observed in response to tissue injury. Several natural products are known to accelerate the process of wound healing. Tetrahydrocurcumin (THC), an in vivo biotransformed product/metabolite of curcumin, is known to exhibit a wide spectrum of biological activities similar to those of native curcuminoids. The poor bioavailability of these curcuminoids limits their clinical applications. The present study highlights the percutaneous absorption and wound healing activity of glucosyl-conjugated THC (glucosyl-THC) in male Wistar rats. A high plasma concentration of glucosyl-THC (4.35 μg/mL) was found in rats 3 hours after application. A significant enhanced wound healing activity and reduced epithelialization time were observed in rats that received glucosyl-THC. This may have been due to the improved bioavailability of the glucosyl compound. The nonstaining and lack of skin-sensitive side effects render the bioconjugated glucosyl-THC a promising therapeutic compound in the management of excision wounds and in cosmetic applications, in the near future. Dove Medical Press 2015-07-13 /pmc/articles/PMC4507491/ /pubmed/26203224 http://dx.doi.org/10.2147/DDDT.S85041 Text en © 2015 Bhaskar Rao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Bhaskar Rao, Adari Prasad, Ernala Deepthi, Seelam Siva Haritha, Vennapusa Ramakrishna, Sistla Madhusudan, Kuncha Surekha, Mullapudi Venkata Venkata Rao, Yerramilli Sri Rama Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title | Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title_full | Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title_fullStr | Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title_full_unstemmed | Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title_short | Wound healing: a new perspective on glucosylated tetrahydrocurcumin |
title_sort | wound healing: a new perspective on glucosylated tetrahydrocurcumin |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507491/ https://www.ncbi.nlm.nih.gov/pubmed/26203224 http://dx.doi.org/10.2147/DDDT.S85041 |
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