The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells

Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP). In this study, we found that pitrilysin, a zinc metallopeptidase of the inverzincin family, degrades m...

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Detalles Bibliográficos
Autores principales: Guan, Hanjun, Chow, K. Martin, Song, Eunsuk, Verma, Nirmal, Despa, Florin, Hersh, Louis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507941/
https://www.ncbi.nlm.nih.gov/pubmed/26191799
http://dx.doi.org/10.1371/journal.pone.0133263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507941/
https://www.ncbi.nlm.nih.gov/pubmed/26191799
http://dx.doi.org/10.1371/journal.pone.0133263

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