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Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain

Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophy...

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Autores principales: Van Den Berge, Nathalie, Vanhove, Christian, Descamps, Benedicte, Dauwe, Ine, van Mierlo, Pieter, Vonck, Kristl, Keereman, Vincent, Raedt, Robrecht, Boon, Paul, Van Holen, Roel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508110/
https://www.ncbi.nlm.nih.gov/pubmed/26193653
http://dx.doi.org/10.1371/journal.pone.0133245
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author Van Den Berge, Nathalie
Vanhove, Christian
Descamps, Benedicte
Dauwe, Ine
van Mierlo, Pieter
Vonck, Kristl
Keereman, Vincent
Raedt, Robrecht
Boon, Paul
Van Holen, Roel
author_facet Van Den Berge, Nathalie
Vanhove, Christian
Descamps, Benedicte
Dauwe, Ine
van Mierlo, Pieter
Vonck, Kristl
Keereman, Vincent
Raedt, Robrecht
Boon, Paul
Van Holen, Roel
author_sort Van Den Berge, Nathalie
collection PubMed
description Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to perform DBS during BOLD fMRI. In this study, we investigate whether DBS during fMRI is valuable to study local and whole-brain effects of hippocampal DBS and to investigate the changes induced by different stimulation intensities. Seven rats were stereotactically implanted with a custom-made MRI-compatible DBS-electrode in the right hippocampus. High frequency Poisson distributed stimulation was applied using a block-design paradigm. Data were processed by means of Independent Component Analysis. Clusters were considered significant when p-values were <0.05 after correction for multiple comparisons. Our data indicate that real-time hippocampal DBS evokes a bilateral BOLD response in hippocampal and other mesolimbic structures, depending on the applied stimulation intensity. We conclude that simultaneous DBS and fMRI can be used to detect local and whole-brain responses to circuit activation with different stimulation intensities, making this technique potentially powerful for exploration of cerebral changes in response to DBS for both preclinical and clinical DBS.
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spelling pubmed-45081102015-07-24 Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain Van Den Berge, Nathalie Vanhove, Christian Descamps, Benedicte Dauwe, Ine van Mierlo, Pieter Vonck, Kristl Keereman, Vincent Raedt, Robrecht Boon, Paul Van Holen, Roel PLoS One Research Article Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to perform DBS during BOLD fMRI. In this study, we investigate whether DBS during fMRI is valuable to study local and whole-brain effects of hippocampal DBS and to investigate the changes induced by different stimulation intensities. Seven rats were stereotactically implanted with a custom-made MRI-compatible DBS-electrode in the right hippocampus. High frequency Poisson distributed stimulation was applied using a block-design paradigm. Data were processed by means of Independent Component Analysis. Clusters were considered significant when p-values were <0.05 after correction for multiple comparisons. Our data indicate that real-time hippocampal DBS evokes a bilateral BOLD response in hippocampal and other mesolimbic structures, depending on the applied stimulation intensity. We conclude that simultaneous DBS and fMRI can be used to detect local and whole-brain responses to circuit activation with different stimulation intensities, making this technique potentially powerful for exploration of cerebral changes in response to DBS for both preclinical and clinical DBS. Public Library of Science 2015-07-20 /pmc/articles/PMC4508110/ /pubmed/26193653 http://dx.doi.org/10.1371/journal.pone.0133245 Text en © 2015 Van Den Berge et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Van Den Berge, Nathalie
Vanhove, Christian
Descamps, Benedicte
Dauwe, Ine
van Mierlo, Pieter
Vonck, Kristl
Keereman, Vincent
Raedt, Robrecht
Boon, Paul
Van Holen, Roel
Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title_full Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title_fullStr Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title_full_unstemmed Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title_short Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain
title_sort functional mri during hippocampal deep brain stimulation in the healthy rat brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508110/
https://www.ncbi.nlm.nih.gov/pubmed/26193653
http://dx.doi.org/10.1371/journal.pone.0133245
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