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Telocytes in mice bone marrow: electron microscope evidence

Telocytes (TCs) are a novel type of interstitial cell of whom presence has been recently documented in many tissues and organs. However, whether TCs exists in bone marrow is still not reported. This study aims to find out TCs in mice bone marrow by using scanning electron microscope (SEM) and transm...

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Detalles Bibliográficos
Autores principales: Li, Hua, Zhang, Hongqi, Yang, Lin, Lu, Shanshan, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508138/
https://www.ncbi.nlm.nih.gov/pubmed/25059385
http://dx.doi.org/10.1111/jcmm.12337
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author Li, Hua
Zhang, Hongqi
Yang, Lin
Lu, Shanshan
Ge, Junbo
author_facet Li, Hua
Zhang, Hongqi
Yang, Lin
Lu, Shanshan
Ge, Junbo
author_sort Li, Hua
collection PubMed
description Telocytes (TCs) are a novel type of interstitial cell of whom presence has been recently documented in many tissues and organs. However, whether TCs exists in bone marrow is still not reported. This study aims to find out TCs in mice bone marrow by using scanning electron microscope (SEM) and transmission electron microscope (TEM). SEM images showed that in mice bone marrow most of TCs have small spherical cell body (usually 4–6 μm diameter) with thin long telopodes (Tps; usually one to three). The longest Tp observed was about 70 μm, with an uneven calibre. Direct intercellular contacts exist between TCs. TEM shows mitochondria within dilations of Tps. Also, by TEM, we show the close spatial relations of Tps with blood vessels. In conclusion, this study provides ultrastructural evidence regarding the existence of TCs in mice bone marrow, in situ.
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spelling pubmed-45081382015-07-22 Telocytes in mice bone marrow: electron microscope evidence Li, Hua Zhang, Hongqi Yang, Lin Lu, Shanshan Ge, Junbo J Cell Mol Med Images in Cellular, Molecular Medicine Telocytes (TCs) are a novel type of interstitial cell of whom presence has been recently documented in many tissues and organs. However, whether TCs exists in bone marrow is still not reported. This study aims to find out TCs in mice bone marrow by using scanning electron microscope (SEM) and transmission electron microscope (TEM). SEM images showed that in mice bone marrow most of TCs have small spherical cell body (usually 4–6 μm diameter) with thin long telopodes (Tps; usually one to three). The longest Tp observed was about 70 μm, with an uneven calibre. Direct intercellular contacts exist between TCs. TEM shows mitochondria within dilations of Tps. Also, by TEM, we show the close spatial relations of Tps with blood vessels. In conclusion, this study provides ultrastructural evidence regarding the existence of TCs in mice bone marrow, in situ. John Wiley & Sons, Ltd 2014-06 2014-07-24 /pmc/articles/PMC4508138/ /pubmed/25059385 http://dx.doi.org/10.1111/jcmm.12337 Text en © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Images in Cellular, Molecular Medicine
Li, Hua
Zhang, Hongqi
Yang, Lin
Lu, Shanshan
Ge, Junbo
Telocytes in mice bone marrow: electron microscope evidence
title Telocytes in mice bone marrow: electron microscope evidence
title_full Telocytes in mice bone marrow: electron microscope evidence
title_fullStr Telocytes in mice bone marrow: electron microscope evidence
title_full_unstemmed Telocytes in mice bone marrow: electron microscope evidence
title_short Telocytes in mice bone marrow: electron microscope evidence
title_sort telocytes in mice bone marrow: electron microscope evidence
topic Images in Cellular, Molecular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508138/
https://www.ncbi.nlm.nih.gov/pubmed/25059385
http://dx.doi.org/10.1111/jcmm.12337
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