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High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men

BACKGROUND: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity. METHODS: In a case-c...

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Autores principales: Biabangard zak, Atefeh, Golalipour, Masoud, Hadadchi, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508339/
https://www.ncbi.nlm.nih.gov/pubmed/26306148
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author Biabangard zak, Atefeh
Golalipour, Masoud
Hadadchi, Gholamreza
author_facet Biabangard zak, Atefeh
Golalipour, Masoud
Hadadchi, Gholamreza
author_sort Biabangard zak, Atefeh
collection PubMed
description BACKGROUND: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity. METHODS: In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation. RESULTS: In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044). CONCLUSION: Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight.
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spelling pubmed-45083392015-08-24 High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men Biabangard zak, Atefeh Golalipour, Masoud Hadadchi, Gholamreza Avicenna J Med Biotechnol Original Article BACKGROUND: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and obesity. METHODS: In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation. RESULTS: In our study, inverse relationship was observed between body mass index and testosterone level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044). CONCLUSION: Our study revealed that Y chromosome microdeletions are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased testosterone level. So, they may contribute to gaining weight. Avicenna Research Institute 2015 /pmc/articles/PMC4508339/ /pubmed/26306148 Text en Copyright© 2015 Avicenna Research Institute This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Biabangard zak, Atefeh
Golalipour, Masoud
Hadadchi, Gholamreza
High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title_full High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title_fullStr High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title_full_unstemmed High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title_short High Prevalence of Y Chromosome Partial Microdeletions in Overweight Men
title_sort high prevalence of y chromosome partial microdeletions in overweight men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508339/
https://www.ncbi.nlm.nih.gov/pubmed/26306148
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