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The Use of Stem Cells in Burn Wound Healing: A Review

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem...

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Autores principales: Ghieh, Fadi, Jurjus, Rosalyn, Ibrahim, Amir, Geagea, Alice Gerges, Daouk, Hisham, El Baba, Bassel, Chams, Sana, Matar, Michel, Zein, Wadih, Jurjus, Abdo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508388/
https://www.ncbi.nlm.nih.gov/pubmed/26236731
http://dx.doi.org/10.1155/2015/684084
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author Ghieh, Fadi
Jurjus, Rosalyn
Ibrahim, Amir
Geagea, Alice Gerges
Daouk, Hisham
El Baba, Bassel
Chams, Sana
Matar, Michel
Zein, Wadih
Jurjus, Abdo
author_facet Ghieh, Fadi
Jurjus, Rosalyn
Ibrahim, Amir
Geagea, Alice Gerges
Daouk, Hisham
El Baba, Bassel
Chams, Sana
Matar, Michel
Zein, Wadih
Jurjus, Abdo
author_sort Ghieh, Fadi
collection PubMed
description Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.
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spelling pubmed-45083882015-08-02 The Use of Stem Cells in Burn Wound Healing: A Review Ghieh, Fadi Jurjus, Rosalyn Ibrahim, Amir Geagea, Alice Gerges Daouk, Hisham El Baba, Bassel Chams, Sana Matar, Michel Zein, Wadih Jurjus, Abdo Biomed Res Int Review Article Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated. Hindawi Publishing Corporation 2015 2015-07-07 /pmc/articles/PMC4508388/ /pubmed/26236731 http://dx.doi.org/10.1155/2015/684084 Text en Copyright © 2015 Fadi Ghieh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ghieh, Fadi
Jurjus, Rosalyn
Ibrahim, Amir
Geagea, Alice Gerges
Daouk, Hisham
El Baba, Bassel
Chams, Sana
Matar, Michel
Zein, Wadih
Jurjus, Abdo
The Use of Stem Cells in Burn Wound Healing: A Review
title The Use of Stem Cells in Burn Wound Healing: A Review
title_full The Use of Stem Cells in Burn Wound Healing: A Review
title_fullStr The Use of Stem Cells in Burn Wound Healing: A Review
title_full_unstemmed The Use of Stem Cells in Burn Wound Healing: A Review
title_short The Use of Stem Cells in Burn Wound Healing: A Review
title_sort use of stem cells in burn wound healing: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508388/
https://www.ncbi.nlm.nih.gov/pubmed/26236731
http://dx.doi.org/10.1155/2015/684084
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