Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen

Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P &l...

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Autores principales: Nguyen, Linh Thuy, Dunford, Linda, Freitas, Ines, Holder, Paul, Nguyen, Lan Anh, O'Gorman, Joanne, Connell, Jeff, Carr, Michael, Hall, William, De Gascun, Cillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508445/
https://www.ncbi.nlm.nih.gov/pubmed/25994168
http://dx.doi.org/10.1128/JCM.01062-15
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author Nguyen, Linh Thuy
Dunford, Linda
Freitas, Ines
Holder, Paul
Nguyen, Lan Anh
O'Gorman, Joanne
Connell, Jeff
Carr, Michael
Hall, William
De Gascun, Cillian
author_facet Nguyen, Linh Thuy
Dunford, Linda
Freitas, Ines
Holder, Paul
Nguyen, Lan Anh
O'Gorman, Joanne
Connell, Jeff
Carr, Michael
Hall, William
De Gascun, Cillian
author_sort Nguyen, Linh Thuy
collection PubMed
description Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic.
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spelling pubmed-45084452015-07-29 Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen Nguyen, Linh Thuy Dunford, Linda Freitas, Ines Holder, Paul Nguyen, Lan Anh O'Gorman, Joanne Connell, Jeff Carr, Michael Hall, William De Gascun, Cillian J Clin Microbiol Virology Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic. American Society for Microbiology 2015-07-20 2015-08 /pmc/articles/PMC4508445/ /pubmed/25994168 http://dx.doi.org/10.1128/JCM.01062-15 Text en Copyright © 2015, Nguyen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Virology
Nguyen, Linh Thuy
Dunford, Linda
Freitas, Ines
Holder, Paul
Nguyen, Lan Anh
O'Gorman, Joanne
Connell, Jeff
Carr, Michael
Hall, William
De Gascun, Cillian
Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title_full Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title_fullStr Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title_full_unstemmed Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title_short Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
title_sort hepatitis c virus core mutations associated with false-negative serological results for genotype 3a core antigen
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508445/
https://www.ncbi.nlm.nih.gov/pubmed/25994168
http://dx.doi.org/10.1128/JCM.01062-15
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