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Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans

Carqueja (Baccharis trimera) is a native plant found throughout South America. Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties. However, studies regarding its antioxidant...

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Autores principales: Aparecida Paiva, Franciny, de Freitas Bonomo, Larissa, Ferreira Boasquivis, Patrícia, Borges Raposo de Paula, Igor Thadeu, Guerra, Joyce Ferreira da Costa, Mendes Leal, Wagney, Silva, Marcelo Eustáquio, Pedrosa, Maria Lúcia, Oliveira, Riva de Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508469/
https://www.ncbi.nlm.nih.gov/pubmed/26236426
http://dx.doi.org/10.1155/2015/740162
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author Aparecida Paiva, Franciny
de Freitas Bonomo, Larissa
Ferreira Boasquivis, Patrícia
Borges Raposo de Paula, Igor Thadeu
Guerra, Joyce Ferreira da Costa
Mendes Leal, Wagney
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Oliveira, Riva de Paula
author_facet Aparecida Paiva, Franciny
de Freitas Bonomo, Larissa
Ferreira Boasquivis, Patrícia
Borges Raposo de Paula, Igor Thadeu
Guerra, Joyce Ferreira da Costa
Mendes Leal, Wagney
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Oliveira, Riva de Paula
author_sort Aparecida Paiva, Franciny
collection PubMed
description Carqueja (Baccharis trimera) is a native plant found throughout South America. Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties. However, studies regarding its antioxidant potential in vivo are limited. In this study, we used Caenorhabditis elegans as a model to examine the antioxidant effects of a Carqueja hydroalcoholic extract (CHE) on stress resistance and lifespan and to investigate whether CHE has a protective effect in a C. elegans model for Alzheimer's disease. Here, we show for the first time, using in vivo assays, that CHE treatment improved oxidative stress resistance by increasing survival rate and by reducing ROS levels under oxidative stress conditions independently of the stress-related signaling pathways (p38, JNK, and ERK) and transcription factors (SKN-1/Nrf and DAF-16/Foxo) tested here. CHE treatment also increased the defenses against β-amyloid toxicity in C. elegans, in part by increasing proteasome activity and the expression of two heat shock protein genes. Our findings suggest a potential neuroprotective use for Carqueja, supporting the idea that dietary antioxidants are a promising approach to boost the defensive systems against stress and neurodegeneration.
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spelling pubmed-45084692015-08-02 Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans Aparecida Paiva, Franciny de Freitas Bonomo, Larissa Ferreira Boasquivis, Patrícia Borges Raposo de Paula, Igor Thadeu Guerra, Joyce Ferreira da Costa Mendes Leal, Wagney Silva, Marcelo Eustáquio Pedrosa, Maria Lúcia Oliveira, Riva de Paula Oxid Med Cell Longev Research Article Carqueja (Baccharis trimera) is a native plant found throughout South America. Several studies have shown that Carqueja has antioxidant activity in vitro, as well as anti-inflammatory, antidiabetic, analgesic, antihepatotoxic, and antimutagenic properties. However, studies regarding its antioxidant potential in vivo are limited. In this study, we used Caenorhabditis elegans as a model to examine the antioxidant effects of a Carqueja hydroalcoholic extract (CHE) on stress resistance and lifespan and to investigate whether CHE has a protective effect in a C. elegans model for Alzheimer's disease. Here, we show for the first time, using in vivo assays, that CHE treatment improved oxidative stress resistance by increasing survival rate and by reducing ROS levels under oxidative stress conditions independently of the stress-related signaling pathways (p38, JNK, and ERK) and transcription factors (SKN-1/Nrf and DAF-16/Foxo) tested here. CHE treatment also increased the defenses against β-amyloid toxicity in C. elegans, in part by increasing proteasome activity and the expression of two heat shock protein genes. Our findings suggest a potential neuroprotective use for Carqueja, supporting the idea that dietary antioxidants are a promising approach to boost the defensive systems against stress and neurodegeneration. Hindawi Publishing Corporation 2015 2015-07-07 /pmc/articles/PMC4508469/ /pubmed/26236426 http://dx.doi.org/10.1155/2015/740162 Text en Copyright © 2015 Franciny Aparecida Paiva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aparecida Paiva, Franciny
de Freitas Bonomo, Larissa
Ferreira Boasquivis, Patrícia
Borges Raposo de Paula, Igor Thadeu
Guerra, Joyce Ferreira da Costa
Mendes Leal, Wagney
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Oliveira, Riva de Paula
Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title_full Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title_fullStr Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title_full_unstemmed Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title_short Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans
title_sort carqueja (baccharis trimera) protects against oxidative stress and β-amyloid-induced toxicity in caenorhabditis elegans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508469/
https://www.ncbi.nlm.nih.gov/pubmed/26236426
http://dx.doi.org/10.1155/2015/740162
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