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Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency

A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent n...

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Autores principales: Anno, Masato, Yamazaki, Takashi, Hara, Nobuhiro, Hayakawa, Keishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508477/
https://www.ncbi.nlm.nih.gov/pubmed/26236521
http://dx.doi.org/10.1155/2015/536592
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author Anno, Masato
Yamazaki, Takashi
Hara, Nobuhiro
Hayakawa, Keishi
author_facet Anno, Masato
Yamazaki, Takashi
Hara, Nobuhiro
Hayakawa, Keishi
author_sort Anno, Masato
collection PubMed
description A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma.
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spelling pubmed-45084772015-08-02 Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency Anno, Masato Yamazaki, Takashi Hara, Nobuhiro Hayakawa, Keishi Case Rep Orthop Case Report A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma. Hindawi Publishing Corporation 2015 2015-07-07 /pmc/articles/PMC4508477/ /pubmed/26236521 http://dx.doi.org/10.1155/2015/536592 Text en Copyright © 2015 Masato Anno et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Anno, Masato
Yamazaki, Takashi
Hara, Nobuhiro
Hayakawa, Keishi
Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title_full Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title_fullStr Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title_full_unstemmed Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title_short Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
title_sort recurrent postoperative spinal epidural hematoma in a patient with protein s deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508477/
https://www.ncbi.nlm.nih.gov/pubmed/26236521
http://dx.doi.org/10.1155/2015/536592
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