Cargando…
Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency
A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent n...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508477/ https://www.ncbi.nlm.nih.gov/pubmed/26236521 http://dx.doi.org/10.1155/2015/536592 |
_version_ | 1782381928571207680 |
---|---|
author | Anno, Masato Yamazaki, Takashi Hara, Nobuhiro Hayakawa, Keishi |
author_facet | Anno, Masato Yamazaki, Takashi Hara, Nobuhiro Hayakawa, Keishi |
author_sort | Anno, Masato |
collection | PubMed |
description | A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma. |
format | Online Article Text |
id | pubmed-4508477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45084772015-08-02 Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency Anno, Masato Yamazaki, Takashi Hara, Nobuhiro Hayakawa, Keishi Case Rep Orthop Case Report A 71-year-old man underwent cervical laminectomy and developed two symptomatic epidural hematomas during the acute postoperative period. On both occasions, drain obstruction was the predominant cause. Congenital Protein S deficiency was diagnosed postoperatively. Protein S is a vitamin K-dependent natural anticoagulant and is essential for inhibiting thrombosis in microcirculation. We assume that Protein S deficiency followed by perioperative bed-rest and surgical invasiveness led to severe hypercoagulability and subsequent drain obstruction. The present findings suggest that both bleeding disorders and hypercoagulability are risk factors for postoperative symptomatic epidural hematoma. Hindawi Publishing Corporation 2015 2015-07-07 /pmc/articles/PMC4508477/ /pubmed/26236521 http://dx.doi.org/10.1155/2015/536592 Text en Copyright © 2015 Masato Anno et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Anno, Masato Yamazaki, Takashi Hara, Nobuhiro Hayakawa, Keishi Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title | Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title_full | Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title_fullStr | Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title_full_unstemmed | Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title_short | Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency |
title_sort | recurrent postoperative spinal epidural hematoma in a patient with protein s deficiency |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508477/ https://www.ncbi.nlm.nih.gov/pubmed/26236521 http://dx.doi.org/10.1155/2015/536592 |
work_keys_str_mv | AT annomasato recurrentpostoperativespinalepiduralhematomainapatientwithproteinsdeficiency AT yamazakitakashi recurrentpostoperativespinalepiduralhematomainapatientwithproteinsdeficiency AT haranobuhiro recurrentpostoperativespinalepiduralhematomainapatientwithproteinsdeficiency AT hayakawakeishi recurrentpostoperativespinalepiduralhematomainapatientwithproteinsdeficiency |