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High frequency synchrony in the cerebellar cortex during goal directed movements

The cerebellum is involved in sensory-motor integration and cognitive functions. The origin and function of the field potential oscillations in the cerebellum, especially in the high frequencies, have not been explored sufficiently. The primary objective of this study was to investigate the spatio-t...

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Autores principales: Groth, Jonathan D., Sahin, Mesut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508504/
https://www.ncbi.nlm.nih.gov/pubmed/26257613
http://dx.doi.org/10.3389/fnsys.2015.00098
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author Groth, Jonathan D.
Sahin, Mesut
author_facet Groth, Jonathan D.
Sahin, Mesut
author_sort Groth, Jonathan D.
collection PubMed
description The cerebellum is involved in sensory-motor integration and cognitive functions. The origin and function of the field potential oscillations in the cerebellum, especially in the high frequencies, have not been explored sufficiently. The primary objective of this study was to investigate the spatio-temporal characteristics of high frequency field potentials (150–350 Hz) in the cerebellar cortex in a behavioral context. To this end, we recorded from the paramedian lobule in rats using micro electro-corticogram (μ-ECoG) electrode arrays while the animal performed a lever press task using the forelimb. The phase synchrony analysis shows that the high frequency oscillations recorded at multiple points across the paramedian cortex episodically synchronize immediately before and desynchronize during the lever press. The electrode contacts were grouped according to their temporal course of phase synchrony around the time of lever press. Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones. The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978). Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex.
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spelling pubmed-45085042015-08-07 High frequency synchrony in the cerebellar cortex during goal directed movements Groth, Jonathan D. Sahin, Mesut Front Syst Neurosci Neuroscience The cerebellum is involved in sensory-motor integration and cognitive functions. The origin and function of the field potential oscillations in the cerebellum, especially in the high frequencies, have not been explored sufficiently. The primary objective of this study was to investigate the spatio-temporal characteristics of high frequency field potentials (150–350 Hz) in the cerebellar cortex in a behavioral context. To this end, we recorded from the paramedian lobule in rats using micro electro-corticogram (μ-ECoG) electrode arrays while the animal performed a lever press task using the forelimb. The phase synchrony analysis shows that the high frequency oscillations recorded at multiple points across the paramedian cortex episodically synchronize immediately before and desynchronize during the lever press. The electrode contacts were grouped according to their temporal course of phase synchrony around the time of lever press. Contact groups presented patches with slightly stronger synchrony values in the medio-lateral direction, and did not appear to form parasagittal zones. The size and location of these patches on the cortical surface are in agreement with the sensory evoked granular layer patches originally reported by Welker's lab (Shambes et al., 1978). Spatiotemporal synchrony of high frequency field potentials has not been reported at such large-scales previously in the cerebellar cortex. Frontiers Media S.A. 2015-07-21 /pmc/articles/PMC4508504/ /pubmed/26257613 http://dx.doi.org/10.3389/fnsys.2015.00098 Text en Copyright © 2015 Groth and Sahin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Groth, Jonathan D.
Sahin, Mesut
High frequency synchrony in the cerebellar cortex during goal directed movements
title High frequency synchrony in the cerebellar cortex during goal directed movements
title_full High frequency synchrony in the cerebellar cortex during goal directed movements
title_fullStr High frequency synchrony in the cerebellar cortex during goal directed movements
title_full_unstemmed High frequency synchrony in the cerebellar cortex during goal directed movements
title_short High frequency synchrony in the cerebellar cortex during goal directed movements
title_sort high frequency synchrony in the cerebellar cortex during goal directed movements
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508504/
https://www.ncbi.nlm.nih.gov/pubmed/26257613
http://dx.doi.org/10.3389/fnsys.2015.00098
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