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Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome

BACKGROUND AND AIM: Small intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal...

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Autores principales: DAVID, LILIANA, BABIN, ALEXANDRU, PICOS, ALINA, DUMITRASCU, DAN LUCIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iuliu Hatieganu University of Medicine and Pharmacy 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508585/
https://www.ncbi.nlm.nih.gov/pubmed/26528017
http://dx.doi.org/10.15386/cjmed-303
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author DAVID, LILIANA
BABIN, ALEXANDRU
PICOS, ALINA
DUMITRASCU, DAN LUCIAN
author_facet DAVID, LILIANA
BABIN, ALEXANDRU
PICOS, ALINA
DUMITRASCU, DAN LUCIAN
author_sort DAVID, LILIANA
collection PubMed
description BACKGROUND AND AIM: Small intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal bacterial overgrowth in irritable bowel syndrome. METHODS: Small intestinal bacterial overgrowth was assessed by the H2 glucose breath test in 90 consecutive patients with irritable bowel syndrome. A check-up of the oral cavity was carried out before the breath testing. Further on, the patients were classified into two groups, positive and negative, at the breath test. Then they were tested for intestinal inflammation with a fecal test for calprotectin. We used a semiquantitative test for this study. Both groups were compared for the association of intestinal inflammation with small intestinal bacterial overgrowth. RESULTS: A number of 24/90 (26.7%) patients with irritable bowel syndrome had small intestinal bacterial overgrowth. A positive test for intestinal inflammation was significantly more frequent in patients with irritable bowel syndrome and small intestinal bacterial overgrowth (chi(2): p<0.05). CONCLUSIONS: Small intestinal bacterial overgrowth is present in almost one quarter of patients with irritable bowel syndrome. It is significantly associated with intestinal inflammation.
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spelling pubmed-45085852015-11-02 Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome DAVID, LILIANA BABIN, ALEXANDRU PICOS, ALINA DUMITRASCU, DAN LUCIAN Clujul Med Original Research BACKGROUND AND AIM: Small intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal bacterial overgrowth in irritable bowel syndrome. METHODS: Small intestinal bacterial overgrowth was assessed by the H2 glucose breath test in 90 consecutive patients with irritable bowel syndrome. A check-up of the oral cavity was carried out before the breath testing. Further on, the patients were classified into two groups, positive and negative, at the breath test. Then they were tested for intestinal inflammation with a fecal test for calprotectin. We used a semiquantitative test for this study. Both groups were compared for the association of intestinal inflammation with small intestinal bacterial overgrowth. RESULTS: A number of 24/90 (26.7%) patients with irritable bowel syndrome had small intestinal bacterial overgrowth. A positive test for intestinal inflammation was significantly more frequent in patients with irritable bowel syndrome and small intestinal bacterial overgrowth (chi(2): p<0.05). CONCLUSIONS: Small intestinal bacterial overgrowth is present in almost one quarter of patients with irritable bowel syndrome. It is significantly associated with intestinal inflammation. Iuliu Hatieganu University of Medicine and Pharmacy 2014 2014-08-05 /pmc/articles/PMC4508585/ /pubmed/26528017 http://dx.doi.org/10.15386/cjmed-303 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Original Research
DAVID, LILIANA
BABIN, ALEXANDRU
PICOS, ALINA
DUMITRASCU, DAN LUCIAN
Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title_full Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title_fullStr Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title_full_unstemmed Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title_short Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome
title_sort small intestinal bacterial overgrowth is associated with intestinal inflammation in the irritable bowel syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508585/
https://www.ncbi.nlm.nih.gov/pubmed/26528017
http://dx.doi.org/10.15386/cjmed-303
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