Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma

We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral multi-targeted kinase inhibitor in Ewing sarcoma. This...

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Autores principales: Attia, Steven, Okuno, Scott H., Robinson, Steven I., Webber, Nicholas P., Indelicato, Daniel J., Jones, Robin L., Bagaria, Sanjay P., Sherman, Courtney, Kozak, Kevin R., Cortese, Cherise M., McFarland, Thomas, Trent, Jonathan C., Maki, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508650/
https://www.ncbi.nlm.nih.gov/pubmed/26266019
http://dx.doi.org/10.4081/rt.2015.5992
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author Attia, Steven
Okuno, Scott H.
Robinson, Steven I.
Webber, Nicholas P.
Indelicato, Daniel J.
Jones, Robin L.
Bagaria, Sanjay P.
Jones, Robin L.
Sherman, Courtney
Kozak, Kevin R.
Cortese, Cherise M.
McFarland, Thomas
Trent, Jonathan C.
Maki, Robert G.
author_facet Attia, Steven
Okuno, Scott H.
Robinson, Steven I.
Webber, Nicholas P.
Indelicato, Daniel J.
Jones, Robin L.
Bagaria, Sanjay P.
Jones, Robin L.
Sherman, Courtney
Kozak, Kevin R.
Cortese, Cherise M.
McFarland, Thomas
Trent, Jonathan C.
Maki, Robert G.
author_sort Attia, Steven
collection PubMed
description We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral multi-targeted kinase inhibitor in Ewing sarcoma. This case provides rationale for adding a Ewing sarcoma arm to SARC024, a phase II study of regorafenib, another multi-targeted kinase inhibitor, in patients with liposarcoma, osteosarcoma and Ewing and Ewing-like sarcomas (NCT02048371). This national multi-institutional study is ongoing.
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spelling pubmed-45086502015-08-11 Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma Attia, Steven Okuno, Scott H. Robinson, Steven I. Webber, Nicholas P. Indelicato, Daniel J. Jones, Robin L. Bagaria, Sanjay P. Jones, Robin L. Sherman, Courtney Kozak, Kevin R. Cortese, Cherise M. McFarland, Thomas Trent, Jonathan C. Maki, Robert G. Rare Tumors Case Report We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral multi-targeted kinase inhibitor in Ewing sarcoma. This case provides rationale for adding a Ewing sarcoma arm to SARC024, a phase II study of regorafenib, another multi-targeted kinase inhibitor, in patients with liposarcoma, osteosarcoma and Ewing and Ewing-like sarcomas (NCT02048371). This national multi-institutional study is ongoing. PAGEPress Publications, Pavia, Italy 2015-05-21 /pmc/articles/PMC4508650/ /pubmed/26266019 http://dx.doi.org/10.4081/rt.2015.5992 Text en ©Copyright S. Attia et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Attia, Steven
Okuno, Scott H.
Robinson, Steven I.
Webber, Nicholas P.
Indelicato, Daniel J.
Jones, Robin L.
Bagaria, Sanjay P.
Jones, Robin L.
Sherman, Courtney
Kozak, Kevin R.
Cortese, Cherise M.
McFarland, Thomas
Trent, Jonathan C.
Maki, Robert G.
Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title_full Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title_fullStr Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title_full_unstemmed Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title_short Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma
title_sort clinical activity of pazopanib in metastatic extraosseous ewing sarcoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508650/
https://www.ncbi.nlm.nih.gov/pubmed/26266019
http://dx.doi.org/10.4081/rt.2015.5992
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