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On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors

Magnetoresistive sensors are widely used for biosensing by detecting the signal from magnetic labels bound to a functionalized area that usually covers the entire sensor structure. Magnetic labels magnetized by a homogeneous applied magnetic field weaken and strengthen the applied field when they ar...

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Detalles Bibliográficos
Autores principales: Henriksen, Anders Dahl, Wang, Shan Xiang, Hansen, Mikkel Fougt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508666/
https://www.ncbi.nlm.nih.gov/pubmed/26195089
http://dx.doi.org/10.1038/srep12282
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author Henriksen, Anders Dahl
Wang, Shan Xiang
Hansen, Mikkel Fougt
author_facet Henriksen, Anders Dahl
Wang, Shan Xiang
Hansen, Mikkel Fougt
author_sort Henriksen, Anders Dahl
collection PubMed
description Magnetoresistive sensors are widely used for biosensing by detecting the signal from magnetic labels bound to a functionalized area that usually covers the entire sensor structure. Magnetic labels magnetized by a homogeneous applied magnetic field weaken and strengthen the applied field when they are over and outside the sensor area, respectively, and the detailed origin of the sensor signal in experimental studies has not been clarified. We systematically analyze the signal from both a single sensor stripe and an array of sensor stripes as function of the geometrical parameters of the sensor stripes as well as the distribution of magnetic labels over the stripes. We show that the signal from sensor stripes with a uniform protective coating, contrary to conventional wisdom in the field, is usually dominated by the contribution from magnetic labels between the sensor stripes rather than by the labels on top of the sensor stripes because these are at a lower height. We therefore propose a shift of paradigm to maximize the signal due to magnetic labels between sensor stripes. Guidelines for this optimization are provided and illustrated for an experimental case from the literature.
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spelling pubmed-45086662015-07-28 On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors Henriksen, Anders Dahl Wang, Shan Xiang Hansen, Mikkel Fougt Sci Rep Article Magnetoresistive sensors are widely used for biosensing by detecting the signal from magnetic labels bound to a functionalized area that usually covers the entire sensor structure. Magnetic labels magnetized by a homogeneous applied magnetic field weaken and strengthen the applied field when they are over and outside the sensor area, respectively, and the detailed origin of the sensor signal in experimental studies has not been clarified. We systematically analyze the signal from both a single sensor stripe and an array of sensor stripes as function of the geometrical parameters of the sensor stripes as well as the distribution of magnetic labels over the stripes. We show that the signal from sensor stripes with a uniform protective coating, contrary to conventional wisdom in the field, is usually dominated by the contribution from magnetic labels between the sensor stripes rather than by the labels on top of the sensor stripes because these are at a lower height. We therefore propose a shift of paradigm to maximize the signal due to magnetic labels between sensor stripes. Guidelines for this optimization are provided and illustrated for an experimental case from the literature. Nature Publishing Group 2015-07-21 /pmc/articles/PMC4508666/ /pubmed/26195089 http://dx.doi.org/10.1038/srep12282 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Henriksen, Anders Dahl
Wang, Shan Xiang
Hansen, Mikkel Fougt
On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title_full On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title_fullStr On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title_full_unstemmed On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title_short On the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
title_sort on the importance of sensor height variation for detection of magnetic labels by magnetoresistive sensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508666/
https://www.ncbi.nlm.nih.gov/pubmed/26195089
http://dx.doi.org/10.1038/srep12282
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