Cargando…

Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme

Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both p...

Descripción completa

Detalles Bibliográficos
Autores principales: Onishi, Manabu, Kurozumi, Kazuhiko, Ichikawa, Tomotsugu, Date, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508716/
https://www.ncbi.nlm.nih.gov/pubmed/24162241
http://dx.doi.org/10.2176/nmc.ra2013-0200
_version_ 1782381980871032832
author Onishi, Manabu
Kurozumi, Kazuhiko
Ichikawa, Tomotsugu
Date, Isao
author_facet Onishi, Manabu
Kurozumi, Kazuhiko
Ichikawa, Tomotsugu
Date, Isao
author_sort Onishi, Manabu
collection PubMed
description Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both play a pivotal role in glioma development. Angiogenesis and invasion are the major factors believed to be responsible for treatment resistance in tumors, and a better understanding of the glioma invasion and angiogenesis mechanisms will lead to the development of potential new treatments. In this review, we focus on the molecular characteristics of angiogenesis and invasion in human malignant glioma. We discuss bevacizumab and cilengitide, which are used to inhibit angiogenesis in GBM.
format Online
Article
Text
id pubmed-4508716
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Japan Neurosurgical Society
record_format MEDLINE/PubMed
spelling pubmed-45087162015-11-05 Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme Onishi, Manabu Kurozumi, Kazuhiko Ichikawa, Tomotsugu Date, Isao Neurol Med Chir (Tokyo) Special Theme Topic: Treatment of Malignant Brain Tumor Despite advances in surgical and medical therapy, glioblastoma multiforme (GBM) remains a fatal disease. There has been no significant increase in survival for patients with this disease over the last 20 years. Tumor vasculature formation and glioma cell invasion along the white matter tracts both play a pivotal role in glioma development. Angiogenesis and invasion are the major factors believed to be responsible for treatment resistance in tumors, and a better understanding of the glioma invasion and angiogenesis mechanisms will lead to the development of potential new treatments. In this review, we focus on the molecular characteristics of angiogenesis and invasion in human malignant glioma. We discuss bevacizumab and cilengitide, which are used to inhibit angiogenesis in GBM. The Japan Neurosurgical Society 2013-11 2013-10-25 /pmc/articles/PMC4508716/ /pubmed/24162241 http://dx.doi.org/10.2176/nmc.ra2013-0200 Text en © 2013 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Special Theme Topic: Treatment of Malignant Brain Tumor
Onishi, Manabu
Kurozumi, Kazuhiko
Ichikawa, Tomotsugu
Date, Isao
Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title_full Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title_fullStr Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title_full_unstemmed Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title_short Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme
title_sort mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme
topic Special Theme Topic: Treatment of Malignant Brain Tumor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508716/
https://www.ncbi.nlm.nih.gov/pubmed/24162241
http://dx.doi.org/10.2176/nmc.ra2013-0200
work_keys_str_mv AT onishimanabu mechanismsoftumordevelopmentandantiangiogenictherapyinglioblastomamultiforme
AT kurozumikazuhiko mechanismsoftumordevelopmentandantiangiogenictherapyinglioblastomamultiforme
AT ichikawatomotsugu mechanismsoftumordevelopmentandantiangiogenictherapyinglioblastomamultiforme
AT dateisao mechanismsoftumordevelopmentandantiangiogenictherapyinglioblastomamultiforme