An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

Cytosolic isocitrate dehydrogenase 1 (IDH1) with an R132H mutation in brain tumors loses its enzymatic activity for catalyzing isocitrate to α-ketoglutarate (α-KG) and acquires new activity whereby it converts α-KG to 2-hydroxyglutarate. The IDH1 mutation induces down-regulation of tricarboxylic aci...

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Detalles Bibliográficos
Autores principales: Miyata, Satsuki, Urabe, Masashi, Gomi, Akira, Nagai, Mutsumi, Yamaguchi, Takashi, Tsukahara, Tomonori, Mizukami, Hiroaki, Kume, Akihiro, Ozawa, Keiya, Watanabe, Eiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508750/
https://www.ncbi.nlm.nih.gov/pubmed/24077277
http://dx.doi.org/10.2176/nmc.oa2012-0409

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