Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury

Autophagy is essentially a metabolic process, but its in vivo role in nuclear radioprotection remains unexplored. We observed that ex vivo autophagy activation reversed the proliferation inhibition, apoptosis, and DNA damage in irradiated hematopoietic cells. In vivo autophagy activation improved bo...

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Detalles Bibliográficos
Autores principales: Lin, Weiwei, Yuan, Na, Wang, Zhen, Cao, Yan, Fang, Yixuan, Li, Xin, Xu, Fei, Song, Lin, Wang, Jian, Zhang, Han, Yan, Lili, Xu, Li, Zhang, Xiaoying, Zhang, Suping, Wang, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508834/
https://www.ncbi.nlm.nih.gov/pubmed/26197097
http://dx.doi.org/10.1038/srep12362

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