Beginning at the end: DNA replication within the telomere

Using single molecule analysis of replicated DNA (SMARD), Drosopoulos et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410061) report that DNA replication initiates at measurable frequency within the telomere of mouse chromosome arm 14q. They demonstrate that resolution of G4 structures...

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Detalles Bibliográficos
Autor principal: Gerbi, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508890/
https://www.ncbi.nlm.nih.gov/pubmed/26195663
http://dx.doi.org/10.1083/jcb.201506078
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author Gerbi, Susan A.
author_facet Gerbi, Susan A.
author_sort Gerbi, Susan A.
collection PubMed
description Using single molecule analysis of replicated DNA (SMARD), Drosopoulos et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410061) report that DNA replication initiates at measurable frequency within the telomere of mouse chromosome arm 14q. They demonstrate that resolution of G4 structures on the G-rich template strand of the telomere requires some overlapping functions of BLM and WRN helicase for leading strand synthesis.
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spelling pubmed-45088902016-01-20 Beginning at the end: DNA replication within the telomere Gerbi, Susan A. J Cell Biol Reviews Using single molecule analysis of replicated DNA (SMARD), Drosopoulos et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201410061) report that DNA replication initiates at measurable frequency within the telomere of mouse chromosome arm 14q. They demonstrate that resolution of G4 structures on the G-rich template strand of the telomere requires some overlapping functions of BLM and WRN helicase for leading strand synthesis. The Rockefeller University Press 2015-07-20 /pmc/articles/PMC4508890/ /pubmed/26195663 http://dx.doi.org/10.1083/jcb.201506078 Text en © 2015 Gerbi This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Gerbi, Susan A.
Beginning at the end: DNA replication within the telomere
title Beginning at the end: DNA replication within the telomere
title_full Beginning at the end: DNA replication within the telomere
title_fullStr Beginning at the end: DNA replication within the telomere
title_full_unstemmed Beginning at the end: DNA replication within the telomere
title_short Beginning at the end: DNA replication within the telomere
title_sort beginning at the end: dna replication within the telomere
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508890/
https://www.ncbi.nlm.nih.gov/pubmed/26195663
http://dx.doi.org/10.1083/jcb.201506078
work_keys_str_mv AT gerbisusana beginningattheenddnareplicationwithinthetelomere

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