Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C

Hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis C virus (HCV) infection. A 49-year-old man receiving pegylated interferon α-2a for HCV infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with HCV RNA undetectable after the 12th...

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Autores principales: Rathi, Chetan, Pipaliya, Nirav, Choksi, Dhaval, Parikh, Pathik, Ingle, Meghraj, Sawant, Prabha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508956/
https://www.ncbi.nlm.nih.gov/pubmed/26203454
http://dx.doi.org/10.14309/crj.2015.74
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author Rathi, Chetan
Pipaliya, Nirav
Choksi, Dhaval
Parikh, Pathik
Ingle, Meghraj
Sawant, Prabha
author_facet Rathi, Chetan
Pipaliya, Nirav
Choksi, Dhaval
Parikh, Pathik
Ingle, Meghraj
Sawant, Prabha
author_sort Rathi, Chetan
collection PubMed
description Hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis C virus (HCV) infection. A 49-year-old man receiving pegylated interferon α-2a for HCV infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with HCV RNA undetectable after the 12th dose. Liver biopsy was suggestive of chronic hepatitis with cirrhosis without interface pattern. Pegylated interferon was discontinued; a few weeks later, his aminotransferases and immunoglobulin levels increased significantly. Antibody to cytosolic liver antigen-1 was positive, and liver biopsy revealed lymphoplasmacytic infiltrate with intense interface hepatitis, consistent with autoimmune hepatitis.
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spelling pubmed-45089562015-07-22 Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C Rathi, Chetan Pipaliya, Nirav Choksi, Dhaval Parikh, Pathik Ingle, Meghraj Sawant, Prabha ACG Case Rep J Case Report Hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis C virus (HCV) infection. A 49-year-old man receiving pegylated interferon α-2a for HCV infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with HCV RNA undetectable after the 12th dose. Liver biopsy was suggestive of chronic hepatitis with cirrhosis without interface pattern. Pegylated interferon was discontinued; a few weeks later, his aminotransferases and immunoglobulin levels increased significantly. Antibody to cytosolic liver antigen-1 was positive, and liver biopsy revealed lymphoplasmacytic infiltrate with intense interface hepatitis, consistent with autoimmune hepatitis. American College of Gastroenterology 2015-07-09 /pmc/articles/PMC4508956/ /pubmed/26203454 http://dx.doi.org/10.14309/crj.2015.74 Text en Copyright © Rathi et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Rathi, Chetan
Pipaliya, Nirav
Choksi, Dhaval
Parikh, Pathik
Ingle, Meghraj
Sawant, Prabha
Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title_full Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title_fullStr Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title_full_unstemmed Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title_short Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
title_sort autoimmune hepatitis triggered by treatment with pegylated interferon α-2a and ribavirin for chronic hepatitis c
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508956/
https://www.ncbi.nlm.nih.gov/pubmed/26203454
http://dx.doi.org/10.14309/crj.2015.74
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