Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture

[Image: see text] The enantiomers of the natural product cycloprodigiosin were prepared using an expedient five-step synthetic sequence that takes advantage of a Schöllkopf–Barton–Zard (SBZ) pyrrole annulation with a chiral isocyanoacetate and a nitrocyclohexene derivative. Using chiral HPLC and X-r...

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Detalles Bibliográficos
Autores principales: Johnson, Rebecca E., de Rond, Tristan, Lindsay, Vincent N. G., Keasling, Jay D., Sarpong, Richmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509414/
https://www.ncbi.nlm.nih.gov/pubmed/26114660
http://dx.doi.org/10.1021/acs.orglett.5b01527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509414/
https://www.ncbi.nlm.nih.gov/pubmed/26114660
http://dx.doi.org/10.1021/acs.orglett.5b01527

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