Cargando…

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

[Image: see text] Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule-induced nonapoptotic cell death, including mediators of fatty acid metabolism (ACSL4) and lipid remodelin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dixon, Scott J., Winter, Georg E., Musavi, Leila S., Lee, Eric D., Snijder, Berend, Rebsamen, Manuele, Superti-Furga, Giulio, Stockwell, Brent R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509420/ https://www.ncbi.nlm.nih.gov/pubmed/25965523 http://dx.doi.org/10.1021/acschembio.5b00245

Ejemplares similares

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

Drosophila Ninjurin A Induces Nonapoptotic Cell Death
por: Broderick, Sarah, et al.
Publicado: (2012)

A substrate‐based ontology for human solute carriers
por: Meixner, Eva, et al.
Publicado: (2020)

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses
por: Köberlin, Marielle S., et al.
Publicado: (2015)

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
por: Rebsamen, Manuele, et al.
Publicado: (2022)

The Role of Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment
por: Hsu, Sheng-Kai, et al.
Publicado: (2022)

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
por: Heinz, Leonhard X., et al.
Publicado: (2015)

Stabilization of ribozyme-like cis-noncoding rRNAs induces apoptotic and nonapoptotic death in lung cells
por: Gee, M, et al.
Publicado: (2012)

Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis
por: Lei, Bin, et al.
Publicado: (2017)

Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer
por: Chen, Rong-Jane, et al.
Publicado: (2018)

A time-resolved molecular map of the macrophage response to VSV infection
por: Kandasamy, Richard K, et al.
Publicado: (2016)

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking
por: Fauster, Astrid, et al.
Publicado: (2018)

Molecularly Engineered Surfactin Analogues Induce Nonapoptotic-Like Cell Death and Increased Selectivity in Multiple Breast Cancer Cell Types
por: Miceli, Rebecca T., et al.
Publicado: (2023)

Cell biology: A key driver of therapeutic innovation
por: Hantschel, Oliver, et al.
Publicado: (2012)

New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway
por: Hsu, Sheng-Kai, et al.
Publicado: (2021)

Drosophila p53 directs nonapoptotic programs in postmitotic tissue
por: Kurtz, Paula, et al.
Publicado: (2019)

Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice
por: Nicholls, P. J., et al.
Publicado: (2022)

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
por: Bigenzahn, Johannes W., et al.
Publicado: (2016)

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells
por: Alam, Antoine, et al.
Publicado: (1999)

TNFα Induces Choroid Plexus Epithelial Cell Barrier Alterations by Apoptotic and Nonapoptotic Mechanisms
por: Schwerk, Christian, et al.
Publicado: (2010)

A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy
por: Tiwari, Meenakshi, et al.
Publicado: (2014)

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
por: Skouta, Rachid, et al.
Publicado: (2014)

Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer
por: Fehm, Tanja, et al.
Publicado: (2006)

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization
por: Huh, Jun R, et al.
Publicado: (2004)

SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
por: Rebsamen, Manuele, et al.
Publicado: (2015)

Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response
por: Hung, Wen-Yueh, et al.
Publicado: (2019)

A structure and evolutionary-based classification of solute carriers
por: Ferrada, Evandro, et al.
Publicado: (2022)

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
por: Sedlyarov, Vitaly, et al.
Publicado: (2018)

Astrocytes and radial glia‐like cells, but not neurons, display a nonapoptotic increase in caspase‐3 expression following exercise
por: Stevenson, Morgan E., et al.
Publicado: (2018)

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
por: Bensimon, Ariel, et al.
Publicado: (2020)

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
por: Ferreira da Silva, Joana, et al.
Publicado: (2019)

Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable”
por: Hantschel, Oliver, et al.
Publicado: (2011)

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
por: Boeszoermenyi, Andras, et al.
Publicado: (2023)

Production of haploids and doubled haploids in oil palm
por: Dunwell, Jim M, et al.
Publicado: (2010)

Salvador–Warts–Hippo pathway regulates sensory organ development via caspase-dependent nonapoptotic signaling
por: Wang, Lan-Hsin, et al.
Publicado: (2019)

Recent advances in combinatorial drug screening and synergy scoring
por: Pemovska, Tea, et al.
Publicado: (2018)

A guide to plasma membrane solute carrier proteins
por: Pizzagalli, Mattia D., et al.
Publicado: (2020)

Current advances in haploid stem cells
por: Cui, Tongtong, et al.
Publicado: (2019)

The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
por: Hartkopf, Andreas Daniel, et al.
Publicado: (2013)

Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
por: Girardi, Enrico, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oo8j4m5bqbcp39kvp62ocm5asj