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Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation

BACKGROUND: Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hypertrophy, fibrosis, an...

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Detalles Bibliográficos
Autores principales:	Zhang, Min, Prosser, Benjamin L., Bamboye, Moradeke A., Gondim, Antonio N.S., Santos, Celio X., Martin, Daniel, Ghigo, Alessandra, Perino, Alessia, Brewer, Alison C., Ward, Christopher W., Hirsch, Emilio, Lederer, W. Jonathan, Shah, Ajay M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Biomedical 2015
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509515/ https://www.ncbi.nlm.nih.gov/pubmed/26184620 http://dx.doi.org/10.1016/j.jacc.2015.05.020

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