The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src

N2-Src is a poorly understood neuronal splice variant of the ubiquitous C-Src tyrosine kinase, containing a 17 amino acid insert in its Src homology 3 (SH3) domain. To characterise the properties of N2-Src we directly compared its SH3 domain specificity and kinase activity with C- and N1-Src in vitr...

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Detalles Bibliográficos
Autores principales: Keenan, Sarah, Lewis, Philip A., Wetherill, Sarah J., Dunning, Christopher J.R., Evans, Gareth J.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509517/
https://www.ncbi.nlm.nih.gov/pubmed/26026271
http://dx.doi.org/10.1016/j.febslet.2015.05.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509517/
https://www.ncbi.nlm.nih.gov/pubmed/26026271
http://dx.doi.org/10.1016/j.febslet.2015.05.033

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