Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons. Here, we take advantage of this model to study...

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Detalles Bibliográficos
Autores principales: Masserdotti, Giacomo, Gillotin, Sébastien, Sutor, Bernd, Drechsel, Daniela, Irmler, Martin, Jørgensen, Helle F., Sass, Steffen, Theis, Fabian J., Beckers, Johannes, Berninger, Benedikt, Guillemot, François, Götz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509553/
https://www.ncbi.nlm.nih.gov/pubmed/26119235
http://dx.doi.org/10.1016/j.stem.2015.05.014

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