Cargando…

Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury

Human kidney is particularly susceptible to ischemia and toxins with consequential tubular necrosis and activation of inflammatory processes. This process can lead to the acute renal injury, and even if the kidney has a great capacity for regeneration after tubular damage, in several circumstances,...

Descripción completa

Detalles Bibliográficos
Autores principales: Sallustio, Fabio, Serino, Grazia, Schena, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509615/
https://www.ncbi.nlm.nih.gov/pubmed/26309808
http://dx.doi.org/10.1089/biores.2015.0011
_version_ 1782382057225191424
author Sallustio, Fabio
Serino, Grazia
Schena, Francesco Paolo
author_facet Sallustio, Fabio
Serino, Grazia
Schena, Francesco Paolo
author_sort Sallustio, Fabio
collection PubMed
description Human kidney is particularly susceptible to ischemia and toxins with consequential tubular necrosis and activation of inflammatory processes. This process can lead to the acute renal injury, and even if the kidney has a great capacity for regeneration after tubular damage, in several circumstances, the normal renal repair program may not be sufficient to achieve a successful regeneration. Resident adult renal stem/progenitor cells could participate in this repair process and have the potentiality to enhance the renal regenerative mechanism. This could be achieved both directly, by means of their capacity to differentiate and integrate into the renal tissues, and by means of paracrine factors able to induce or improve the renal repair or regeneration. Recent genetic fate-tracing studies indicated that tubular damage is instead repaired by proliferative duplication of epithelial cells, acquiring a transient progenitor phenotype and by fate-restricted clonal cell progeny emerging from different nephron segments. In this review, we discuss about the properties and the reparative characteristics of high regenerative CD133(+)/CD24(+) cells, with a view to a future application of these cells for the treatment of acute renal injury.
format Online
Article
Text
id pubmed-4509615
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Mary Ann Liebert, Inc.
record_format MEDLINE/PubMed
spelling pubmed-45096152015-08-25 Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury Sallustio, Fabio Serino, Grazia Schena, Francesco Paolo Biores Open Access Comprehensive Review Human kidney is particularly susceptible to ischemia and toxins with consequential tubular necrosis and activation of inflammatory processes. This process can lead to the acute renal injury, and even if the kidney has a great capacity for regeneration after tubular damage, in several circumstances, the normal renal repair program may not be sufficient to achieve a successful regeneration. Resident adult renal stem/progenitor cells could participate in this repair process and have the potentiality to enhance the renal regenerative mechanism. This could be achieved both directly, by means of their capacity to differentiate and integrate into the renal tissues, and by means of paracrine factors able to induce or improve the renal repair or regeneration. Recent genetic fate-tracing studies indicated that tubular damage is instead repaired by proliferative duplication of epithelial cells, acquiring a transient progenitor phenotype and by fate-restricted clonal cell progeny emerging from different nephron segments. In this review, we discuss about the properties and the reparative characteristics of high regenerative CD133(+)/CD24(+) cells, with a view to a future application of these cells for the treatment of acute renal injury. Mary Ann Liebert, Inc. 2015-07-01 /pmc/articles/PMC4509615/ /pubmed/26309808 http://dx.doi.org/10.1089/biores.2015.0011 Text en © Fabio Sallustio et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Comprehensive Review
Sallustio, Fabio
Serino, Grazia
Schena, Francesco Paolo
Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title_full Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title_fullStr Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title_full_unstemmed Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title_short Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury
title_sort potential reparative role of resident adult renal stem/progenitor cells in acute kidney injury
topic Comprehensive Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509615/
https://www.ncbi.nlm.nih.gov/pubmed/26309808
http://dx.doi.org/10.1089/biores.2015.0011
work_keys_str_mv AT sallustiofabio potentialreparativeroleofresidentadultrenalstemprogenitorcellsinacutekidneyinjury
AT serinograzia potentialreparativeroleofresidentadultrenalstemprogenitorcellsinacutekidneyinjury
AT schenafrancescopaolo potentialreparativeroleofresidentadultrenalstemprogenitorcellsinacutekidneyinjury