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Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

BACKGROUND: Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes to the development of DCM. ROCK targets several sarcomeric proteins including...

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Detalles Bibliográficos
Autores principales:	Waddingham, Mark T, Edgley, Amanda J, Astolfo, Alberto, Inagaki, Tadakatsu, Fujii, Yutaka, Du, Cheng-Kun, Zhan, Dong-Yun, Tsuchimochi, Hirotsugu, Yagi, Naoto, Kelly, Darren J, Shirai, Mikiyasu, Pearson, James T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509700/ https://www.ncbi.nlm.nih.gov/pubmed/26194354 http://dx.doi.org/10.1186/s12933-015-0256-6

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